Adult Oral Oxycodone vs IV Morphine study: Data Sheet, Study Flow, Data Collection Tips, FAQs

Overview:  This study will determine if an equianalgesic dose of oral oxycodone is comparable to IV morphine for the treatment of pain from musculoskeletal injuries in the ED.

Primary Endpoints: 1. Patient pain as assessed by VAS at 10, 20, 30, and 40 post administration of medication.

Eligible Patients: Patients greater than 18 years old who were going to receive morphine for pain management.  Patients who are pregnant or nursing, are intoxicated, have an allergy to morphine or oxycodone, or have a history of kidney or liver disease are ineligible.
 

Study Design: Prospective, randomized clinical trial.
 

Anticipated Benefits: Patient may receive pain relief during participation in study.  Patients randomized to oral oxycodone group may receive relief without IV placement.
 

Potential Risks: Risks associated with narcotic medications, potential for respiratory depression.
 

Research Associate’s Role:  Research Associates are responsible for identifying eligible patients for this study and recruiting them.  Review the exclusion criteria detailed in the study packet with the patient’s physician prior to enrollment.
 

Physician’s Role: Physicians will complete a 100 mm VAS at each time point representing their perception of the patient’s pain.  After 40 minutes, the physician will determine if the pain treatment was sufficient, and further therapy can be initiated per standard patient care. The patient will be started on IV morphine if the physician feels the patient is having insufficient relief of pain after 30 minutes and this will be considered treatment failure.

Location of Study Packets: Team Center B